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ALS drugs from Denali, Calico come up short, marking setback for Healey trial
Denali’s medicine and a similar one from Calico Life Sciences and AbbVie were not much different than a placebo, bringing the tally of failed drugs in the innovative “Healey platform trial” to seven.
Denali Therapeutics' ALS drug fails in mid-to-late stage trial
Denali Therapeutics said on Monday its experimental drug failed to meet the main goal of a mid-to-late stage trial involving patients with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease.
Denali Therapeutics announces HEALEY ALS trial regimen misses endpoints
Denali Therapeutics (DNLI) announced topline results from an analysis of Regimen G of the Phase 2/3 HEALEY ALS Platform Trial evaluating eIF2B
STAT
2d
Google’s secretive anti-aging company Calico finally released data. Its drug failed
The company said Monday that fosigotifator failed to outperform placebo in slowing the neurodegenerative disease, but is ...
FierceBiotech
2d
Rival AbbVie and Denali prospects flunk phase 2/3 ALS tests, denting hopes for shared mechanism
AbbVie, Calico and Denali Therapeutics’ hopes of treating amyotrophic lateral sclerosis (ALS) by targeting eIF2B have all ...
Crain's Chicago Business
1d
AbbVie and rival's ALS drugs both disappoint in study
In studies by Massachusetts General Hospital, the AbbVie-Calico collaborative drug and Denali Therapeutics' own drug failed to meet endpoints for treating amyotrophic lateral sclerosis, more widely ...
STAT
2d
Pharmalittle: We’re reading about FDA guidance on AI, meds releasing ‘forever chemicals,’ and more
The FDA published its first draft guidance on the use of AI in the development of drugs and biological products ...
The Pharma Letter
1d
Calico next to fail in ALS
Calico Life Sciences, a biotech founded by Alphabet and Arthur Levinson focused on the biology of aging and age-related ...
Pharmaceutical Technology
3d
Fosigotifator by Calico Life Sciences for Unspecified Central Nervous System Disorders: Likelihood of Approval
Fosigotifator is under clinical development by Calico Life Sciences and currently in Phase II for Unspecified Central Nervous System Disorders.
Hosted on MSN
2d
Fierce bird attacks calico cat lurking under its tree
A fierce bird attacked a calico cat lurking under its tree territory. Footage shows the oriental magpie robin swooping down ...
3d
Maple Street Biscuit Co. co-founder launching competing brunch taco and coffee concept
Twelve years after launching the successful Maple Street Biscuit Co. chain, co-founder Scott Moore is set to debut a new and ...
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Google
Denali
AbbVie Inc.
Amyotrophic lateral sclerosis
fosigotifator
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