No. 4 Penn State travels to the West Coast for a much-anticipated clash with USC on Saturday. This weekend's showdown will mark the 11th meeting between the proud programs and the first since USC's 52-49 win in the Rose Bowl over Penn State in 2017.

USC will likely be without two of its most important defensive players for their pivotal matchup against Penn State on Oct. 12

In the Trojan’s first year in the Big Ten, they have an opportunity to make a statement against the Nittany Lions.