Newsweek Sports' expert predictions for Detroit Lions vs. San Francisco 49ers on Monday Night Football Week 17.

Lions, the NFL Week 18 schedule and more. More: NFL Week 17 winners, losers: Colts flame out in epic fashion with elimination loss to Giants Watch Monday Night Football with Fubo What time does the Monday Night Football Lions-49ers game start tonight for NFL Week 17?

We're discussing Gibbs' workload, the 49ers' current situation and Detroit's newly configured defensive backfield.

Listing our expert Penn Live picks of the best prop bets and odds available for tonight's Monday Night Football NFC matchup between the Lions and 49ers.

Here are the two critical matchups to watch on MNF between Detroit Lions and San Francisco 49ers in Week 17, including Penei Sewell against Nick Bosa.

Week 17 has been full of games with playoff implications. The Monday Night Football conclusion to the week, featuring the Detroit Lions visiting the San Francisco 49ers, is one of the few games that really does not impact the postseason.

This isn't the same 49ers team the Lions lined up against 11 months ago, but Detroit is still treating it like a marquee game.

The 49ers are eliminated from the playoffs. But don't tell Kittle or Samuel that, with both studs having two of their best games of the year last week.

Detroit Lions head coach Dan Campbell made his intentions clear when asked about Monday night's primetime NFC Championship Game rematch against the San Francisco 49ers—the team that ended Detroit's Super Bowl hopes last season.