A year ago, the 49ers beat the Lions in the NFC Championship at Levi's Stadium. What a difference a year makes. On Thursday, Nick Bosa stood at his locker and discusses the 49ers' disastrous season in relation to the Lions' continued success.

Ruled out Friday were left tackle Trent Williams (for the fifth straight game) and running back Isaac Guerendo (hamstring, foot; started two previous games). Defensive end Robert Beal Jr. (ankle) is also out, as are tight end Jake Tonges, defensive tackle Khalil Davis, and cornerback Rock Ya-Sin; Josh Dobbs is the No. 3 emergency quarterback.

On Monday in the 49ers locker room, Nick Bosa was asked about De'Vondre Campbell quitting on the team. Here's what Bosa said. Q: Did you guys see

San Francisco 49ers edge rusher Nick Bosa clarified his run-in with Miami Dolphins coach after their Week 16 meeting at Hard Rock Stadium.

The San Francisco 49ers face unexpected challenges this season, with a 6-9 record and playoff hopes dashed. Defensive star Nick Bosa acknowledges frequent penalties and injuries as major issues. As they prepare for a rematch against the Detroit Lions,

The 49ers will have their best pass rusher today. Defensive end Nick Bosa officially is active for the 49ers' Week 16 game against the Miami Dolphins.

After Sunday's game at Hard Rock Stadium, San Francisco 49ers defensive end Nick Bosa and Miami Dolphins head coach Mike McDaniel shared a lighthearted postgame exchange on the field.