Cite this: Abl Tyrosine Kinase Inhibitors for Overriding Bcr-Abl/T315I: From the Second to Third Generation - Medscape - Sep 01, 2008.

Abl tyrosine kinase activity was determined using a synthetic peptide (EAIYAAPFAKKK) as substrate. The activities of Lyn and Csk tyrosine kinases were assayed using a Src substrate peptide ...

We have found that inhibition of the BCR–ABL tyrosine kinase, either by mutation or by the drug STI571, can stimulate its nuclear entry. By combining STI571 with leptomycin B (LMB) to block ...

As the disease progresses, it’s important to regularly adapt treatment strategies based on consistent monitoring of BCR-ABL levels ... My Current Treatment? Tyrosine kinase inhibitors (TKIs ...