Kaleido Scope5y
CFTR Rat Models Core
in addition to maintenance of wild-type Sprague Dawley strain for additional use Generation and procurement of novel relevant CF animal models to understand newly developed CFTR modulators, and to ...
Nature6y
A disease called 'sixty-five roses'
The CFTR gene was identified in 1989 ... Structural GenomiX accepted $11 million over five years to solve the structure of CFTR, with additional payments along the way for reaching critical ...
The Scientist5mon
A Gene Editing System Corrects Cystic Fibrosis Mutation
In their 2019 paper, Liu’s team used prime editing to alter the gene mutations causing sickle cell disease and Tay-Sachs disease. Liu explained that they attempted to edit mutated CFTR as well but ...
Kaleido Scope4y
Animal and Preclinical Models Core
The North Carolina knockout mouse (Cftr tm1Unc) line: Contain a Neo cassette in exon 10 of the murine Cftr gene and exhibit a severe phenotype ... conduct thorough histopathologic analyses of airway ...
Nanowerk8mon
Cytosine in DNA and RNA: Functions, Modifications, and Applications
This image depicts the chemical structure of cytosine. It shows a hexagonal ring with ... Cystic fibrosis: Mutations in the CFTR gene, often involving cytosine, disrupt the function of chloride ...