Ion channel proteins are found on all cell types and allow the passage of ions across cellular membranes. They are involved in a wide variety of biological processes and are implicated in many ...

Novartis AG has synthesized new sodium channel protein type 5 subunit alpha (SCN5A; Nav1.5) blockers reported to be useful for the treatment of heart failure, long QT syndrome, hypertrophic ...

Here, we use a synthetic amphiphile to modulate the membrane mechanical properties of cell-derived vesicles and probe channel activation. Using precise membrane mechanical characterization approaches ...

A study in the journal Pharmaceuticals has uncovered how specific genetic mutations in α2δ-1 and α2δ-3 proteins linked to ...