First, a genetic deletion of an HDAC results in the complete absence of the enzyme, whereas inhibitors do not result in complete inhibition of activity. Second, a genetic deletion of an HDAC ...

Inhibitors of histone deacetylase (HDAC) enzymes have been shown to improve learning and memory; however, multiple forms of HDAC exist, and the development of more effective HDAC inhibitors would ...

further strengthening Shuttle Pharma’s intellectual property portfolio and supporting its ongoing efforts to develop novel therapeutics targeting histone deacetylase (HDAC) enzymes. The newly ...

The investigational therapy CS1 led to beneficial changes in for people with pulmonary arterial hypertension in a Phase 2a ...

Discover six innovative clinical-stage biotech companies fostering R&D in the Duchenne muscular dystrophy therapeutic space.

Targeting an enzyme called histone deacetylase (HDAC) has delivered among the most exciting progress in exploiting epigenetics so far. HDAC normally regulates gene expression viamodification of the ...

The sample on the right is from a mouse in which "enzyme-dead" HDAC3 is preventing the fatty liver. Note that there is much less red staining, even though the HDAC3 does not possess the enzyme ...

Zhijian “James” Chen, a biochemist at the University of Texas Southwestern Medical Center, was awarded the 2024 Albert Lasker Basic Medical Research Award for the discovery of the cGAS enzyme that ...

A popular experiment that's recommended to demonstrate the functionality of enzymes is chewing a piece of bread for a moment, then paying attention to when it turns from a starchy flavor to begin ...

How does your body speed up these important reactions? The answer is enzymes. Enzymes in our bodies are catalysts that speed up reactions by helping to lower the activation energy needed to start a ...

A research team led by the University of California, Irvine has engineered an efficient new enzyme that can produce a synthetic genetic material called threose nucleic acid. The ability to ...