Research over the past decade has revealed multiple potential mechanisms by which dendritic cells contribute to the immunopathogenesis of systemic lupus erythematosus. Genetic abnormalities in ...

Neuropsychiatric systemic lupus erythematosus (NPSLE), or central nervous system lupus, can be challenging to diagnose ...

Pathogenesis is the term that is used to describe ... Treating a mouse model of systemic lupus erythematosus with simvastatin (an inhibitor of this pathway) led to recovery from dysregulation ...

People with lupus often need to use medicines to manage their symptoms. Although there are many oral medicines that treat lupus, some people with more severe symptoms may not get enough benefit ...

While the same can be said of many other diseases with diverse presentations—including lupus, multiple sclerosis, or psychiatric illnesses—the lack of a clear definition or disease pathway ...

Now, the company has hit the brakes on its phase 2b study of the drug in lupus nephritis following four patient fatalities. An independent data monitoring committee (IDMC) recommended suspending ...

The increasing prevalence of autoimmune and immune-mediated diseases (AIMDs) underscores the need to understand environmental ...

Asthma affects approximately 262 million people globally, with the number of asthma incidents having increased by around 15% ...

Patients with rheumatologic diseases are far more likely to experience mood disorders, including anxiety and depression.

To date, treatment with NIM-1324 has reduced the production of interferon alpha in human peripheral blood mononuclear cells (PBMCs) from systemic lupus erythematosus (SLE) patients and provided ...

Future Rheumatol. 2008;3(3):269-279. These phenotypic abnormalities, at least in part, appear to be intrinsic to the mDCs, as the addition of lupus serum to healthy control or lupus mDCs could not ...