Under stress, mitochondria rapidly increase their copy number—that is, the number of mitochondrial genomes in each organelle—as part of a process called the mitochondrial unfolded protein response, or ...
A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...
"Given the high conservation of TGF-β signaling, manipulating TGF-β pathways to coordinate mitochondrial stress responses and ...
Although previous work had indirectly suggested that changing mitochondrial function affected lifespan, “this is the first clear demonstration [that it] extends mouse lifespan,” Miller added. It’s ...
Studies show cell-free DNA (cfDNA), including cf-nDNA and cf-mtDNA, is released during stress, offering a potential biomarker ...
As a team we are dedicated to improve the life of patients with mitochondrial disease by understanding the mechanisms underlying these maladies that have no treatment option to date.
Whether cells in the human body survive or die under stress depends, among other things, on their mitochondria ... and instead triggers an inflammatory response. The results of this research ...
Exonuclease action of replicative polymerase gamma drives damage-induced mitochondrial DNA clearance
How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...
the role of NAD+ metabolism in mitochondrial diseases and its curative effect and mitochondrial stress response, especially in a tissue-specific manner. I am a mom to two small kids and love spending ...
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