Although this approach has met with limited success for such genes as CFTR, which encodes the cystic fibrosis transmembrane ... a large gene by the split AAV vectors through heterodimerization.

Experiments and modeling reveal the unexpected structure that can be seen in bacteria grown in mucus samples and biofilms.

Yet, the limitations of the technologies used to get the nucleic ... to treat diseases such as cystic fibrosis that are beyond the packaging capacity of viral vectors, and combine DNA and RNA ...