Decades ago, psoriasis was thought to be driven by the keratinocytes in the epidermis. The discovery that immune cells mediated the disease explained the efficacy of immunosuppressive therapies ...

Under the microscope, psoriasis and lichen planus both have an acanthotic appearance. But with lichen planus, there will be a band-like area of damage between the upper layer of skin (epidermis) and ...

Furthermore, studies have identified high levels of iron in the skin of psoriasis patients. The epidermis of psoriasis patients is also known to produce high levels of hepcidin, which is thought ...

Psoriasis vulgaris is a disease of the interfollicular epidermis, and it does not significantly alter the growth of follicular epithelia or the normal hair growth cycle. Rarely, a few small pustules ...

investigated whether IL-21 can induce keratinocyte proliferation and epidermal hyperplasia as seen in psoriasis ... and infiltration of the dermis and epidermis with inflammatory cells.

Dry, oily and normal epidermis. Skin problems, acne, blackheads, psoriasis and vitiligo vector set 3d human skin types cross section layers. Dry, oily and normal epidermis. Skin problems, acne, ...

showed that KO of Sema4A in non-hematopoietic cells was responsible for the enhanced inflammation in psoriasis. The expression of CCL20, TNF, IL-17, and mTOR was upregulated in the Sema4AKO epidermis ...

The loss or reduction of Jun expression in the epidermis relieves a block on cytokine expression. As a consequence, the increased levels of cytokines in mice lead to diseases reminiscent of psoriasis ...

Herein, we investigated the roles of Sema4A in the pathogenesis of psoriasis by analyzing skin and blood specimens from psoriatic subjects and using a murine model. Taken together, it is suggested ...