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Upping AMPK. In response to calorie restriction, LCA binds TULP3, activating sirtuins and triggering deacetylation of lysines on the V1E1 subunit of the lysosomal V-ATPase. This slows the proton pump, ...

A rare genetic disorder affecting copper levels in the body, Menkes disease is caused by mutations in the ATPase Copper Transporting Alpha (ATP7A) gene. Give your business an edge with our leading ...

By utilizing immunoprecipitation, mass spectrometry, and mutational studies, it was demonstrated that MNS binds to the LRR and NACHT domains and suppresses ATPase activity of NLRP3, while the ...

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Gram-negative bacteria, especially Enterobacterales, have emerged as major players in antimicrobial resistance worldwide. Resistance may affect all major classes of anti-gram-negative agents, becoming ...

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This important work identifies a non-autophagic role for ATG5 in lysosomal repair and the trafficking of the glucose transporter GLUT1 to the cell surface, mediated through the retromer complex. The ...

Data presented in this useful report suggest a potentially new model for chemotaxis regulation in the gram-negative bacterium P. putida. Data supporting interactions between CheA and the ...