Safeguarding intestinal stem cells during aging through balanced signaling
A recent study led by Associate Professor Takuya Yamamoto and Researcher May Nakajima-Koyama has revealed that maintaining a ...
Frontiers16d
Phase-dependent iron depletion differentially regulates the niche of intestinal stem cells in experimental colitis via ERK/STAT3 signaling pathway
However, the role and mechanism of iron in the phase of enteritis and the subsequent repairing phase of intestinal ... Meanwhile, cell culture and colonic organoids were used to examine the influence ...
Brock University25d
Brock-led research manipulates cell signalling as potential cancer therapy
A Brock-led research team has discovered a mechanism that provides new insights into stopping the spread of various cancers by controlling a stage of cell signalling, a process through which cells ...
eLife1mon
3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
Overall, the results will be of interest to both the fields of 3D genome architecture and pediatric obesity. To explore the enrichment of childhood obesity GWAS variants across cell types, we carried ...
ascopubs.org1mon
Chimeric Antigen Receptor-T Cells in Colorectal Cancer: Pioneering New Avenues in Solid Tumor Immunotherapy
Chimeric antigen receptor-T (CAR-T) cell therapy, initially successful in hematologic malignancies, presents a promising avenue for treating solid tumors, including CRC. This review explores the ...
Frontiers1mon
Primary cilia-associated signalling in squamous cell carcinoma of head and neck region
Here, we introduce cilia-related signalling in head and neck squamous cell carcinoma (HNSCC) and its possible association with HNSCC tumorigenesis. From this point of view, PDGF, EGF, Wnt and Hh ...
eLife1mon
Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway
Therefore, this manuscript offers novel insights into the mechanism of nicotine's effects on the mouse intestine. The manuscript by Isotani et al characterizes the hyperproliferation of intestinal ...
Cancer Research1mon
American Association for Cancer Research
This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. This work is licensed under a Creative Commons Attribution 4.0 International ...
GitHub2mon
HiCFoundation is a generalizable Hi-C foundation model for chromatin architecture, single-cell and multi-omics analysis across species.
A generalizable Hi-C foundation model for chromatin architecture, single-cell and multi-omics analysis across species. bioRxiv, 2024. Paper @article{wang2024hicfoundation, title={A generalizable Hi-C ...