With the latest injury to WR Brandon Aiyuk, the 49ers will have to find ways to win using their depth players.

The 49ers and wide receiver Brandon Aiyuk got the worst news on his injured right knee. According to a report from Fox Sports ...

Injuries always have a significant effect on the NFL season, but some teams are bearing the brunt of absences more than ...

On Monday, San Francisco 49ers wide receiver Deebo Samuel expressed his support for his injured teammate, Brandon Aiyuk. Head ...

Mike Florio and Devin McCourty react to the latest news out of San Francisco, discussing Brandon Aiyuk’s season-ending injury ...

The hits just keep on coming for the San Francisco 49ers. Bruce Springsteen says paying his band 'a tremendous amount of money' has been key to his career success and longevity ...

San Francisco 49ers star receiver Deebo Samuel has been released from the hospital after being treated for a bout of ...

San Francisco 49ers face offensive challenges as injuries mount, leaving Purdy with limited options in loss to Kansas City ...

The 49ers’ lone screen on Sunday went to rookie Jacob Cowing, who gained nine yards. It’s something he did well in college.

It isn’t news that running back and reigning Offensive Player of the Year Christian McCaffrey is a key cog in the 49ers’ ...

When Ricky Pearsall finally made his debut for the San Francisco 49ers in Week 7, it felt like a special moment not just for fans of the red and gold but of the NFL, period. A first-round pick, fresh ...