in addition to maintenance of wild-type Sprague Dawley strain for additional use Generation and procurement of novel relevant CF animal models to understand newly developed CFTR modulators, and to ...
The CFTR gene was identified in 1989 ... Structural GenomiX accepted $11 million over five years to solve the structure of CFTR, with additional payments along the way for reaching critical ...
The North Carolina knockout mouse (Cftr tm1Unc) line: Contain a Neo cassette in exon 10 of the murine Cftr gene and exhibit a severe phenotype ... conduct thorough histopathologic analyses of airway ...
This image depicts the chemical structure of cytosine. It shows a hexagonal ring with ... Cystic fibrosis: Mutations in the CFTR gene, often involving cytosine, disrupt the function of chloride ...
Modulator drugs interact with mutant CFTR and force abnormally-folded proteins into a more functional structure ... mutations that prematurely halt gene expression, and are not amenable to ...
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