Non-transfusion-dependent thalassemia encompasses three clinically distinct forms -- beta-thalassaemia intermedia, hemoglobin E/beta-thalassaemia (mild and moderate forms), and al ...

49 Extramedullary hematopoiesis has been observed in tissues such as the liver, spleen, and adipose tissue. In these cases, pathogenic stimuli lead to the recruitment of HSC/HSPCs from the bone marrow ...

Dahdaleh et al. elucidated an alternative pathophysiological mechanism, suggesting that chronic extramedullary hematopoiesis, observed in sickle cell disease, contributes to cortical thinning of the ...

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

Clonal hematopoiesis (CH) has been associated with a variety of adverse outcomes, most notably hematologic malignancy and ischemic cardiovascular disease. A series of recent studies also suggest that ...

NAINR. 2004;4(4):231-239. Acanthocyte Erythrocyte identified by numerous spiny cytoplasmic projections; similar to a Burr cell Acanthocytosis, condition in which the majority of erythrocytes are ...

Genetic mutations in the β-globin gene lead to a decrease or removal of the β-globin chain, causing the build-up of unstable alpha-hemoglobin. This condition is referred to as beta-thalassemia (BT).