49 Extramedullary hematopoiesis has been observed in tissues such as the liver, spleen, and adipose tissue. In these cases, pathogenic stimuli lead to the recruitment of HSC/HSPCs from the bone marrow ...

1,2 This is exacerbated by extramedullary hematopoiesis, which causes splenomegaly and hepatomegaly. Other signs and symptoms of primary myelofibrosis include severe anemia, fatigue, nocturnal ...

Non-transfusion-dependent thalassemia encompasses three clinically distinct forms -- beta-thalassaemia intermedia, hemoglobin E/beta-thalassaemia (mild and moderate forms), and al ...

Clonal hematopoiesis (CH) has been associated with a variety of adverse outcomes, most notably hematologic malignancy and ischemic cardiovascular disease. A series of recent studies also suggest that ...

In adults, haematopoiesis occurs mainly in the bone marrow (medullary), but it can also occur in other tissues such as the liver, thymus and spleen (extramedullary). IRE1α–XBP1 safeguards ...

Myelosuppression, or bone marrow suppression, is defined as a decrease in the ability of the bone marrow to produce blood cells. This may result in a lack of red blood cells (anemia), white blood ...