"Both the TET2 and ASXL1 genes can be mutated, individually or together, in clonal hematopoiesis, leukemia, and a premalignant form of cancer called myelodysplastic syndrome," says Dong.

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

"Both the TET2 and ASXL1 genes can be mutated, individually or together, in clonal hematopoiesis, leukemia, and a premalignant form of cancer called myelodysplastic syndrome," says Dong.

"Both the TET2 and ASXL1 genes can be mutated, individually or together, in clonal hematopoiesis, leukemia, and a premalignant form of cancer called myelodysplastic syndrome," says Dong.

Dana-Farber Cancer Institute researchers have identified factors that determine whether donor lymphocyte infusion (DLI), a ...

Myelodysplastic syndromes (MDS) are marked by ineffective hematopoiesis and dysplasia, which elevate the risk of progression to acute myeloid leukemia (AML). The inflammatory environment in MDS alters ...