Aging is inevitable for most cell types in the human body, but hematopoietic stem cells (HSCs) seem to defy the process. They retain their self-renewing ability almost throughout an organism’s ...

Researchers find that certain antioxidant enzymes, called selenoproteins, significantly contribute to fighting cell aging. The team used a gene knockout mouse model to help them study the effects of ...

Scientist Sarallah Rezazadeh from the Icahn School of Medicine explores the molecular mechanisms behind adult stem cells as ...

Nothing lives forever, but compared to other cells in the body, hematopoietic stem cells ... cyclophilin A accelerated natural aging in the stem cell compartment. In contrast, reintroducing ...

Will and her colleagues showed that young mouse hematopoietic stem cells tightly regulate iron homeostasis to keep intracellular iron levels low, a capacity which may be lost during aging. 1 ...

Since aging is widely associated with systemic ... More information: Yun-Ruei Kao et al, An iron rheostat controls hematopoietic stem cell fate, Cell Stem Cell (2024). DOI: 10.1016/j.stem.

Our body is constantly repaired and renewed by tissue-specific stem cells (aka. adult stem cells). In order to secure tissue homeostasis, generation of new stem cells via self-renewal and their ...

Hidden within our bones, marrow sustains life by producing billions of blood cells daily, from oxygen-carrying red cells to immune-boosting white cells. This vital function is often disrupted in ...

Because B-cell lymphoma develops in a type of white blood cell, the team examined their precursors, called hematopoietic stem cells, in the mice. Genetically disrupting inflammasome activity in ...