Metabolic requirements of dividing hepatocytes are prerequisite for liver regeneration after injury. In contrast to transcriptional dynamics during liver repair, its metabolic dependencies remain ...
Van Dorp, D. A., Van Der Zijden, A. S. N., Beerthuis, R. K., Spaareboom, S., Ord, W. O., De Jong, K., and Kenuing, R., Rev. Trav. Chim., 82, 587 (1963).
In summary, the expression of ferroptosis markers GPX4 and SLC7A11 is regulated by the AKT/GSK3β/β-catenin signaling pathway, and PFOA may promote hepatocyte ferroptosis by inhibiting this pathway.
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