Most cell signals are chemical in nature. For example, prokaryotic organisms have sensors that detect nutrients and help them navigate toward food sources. In multicellular organisms, growth ...

A simplified signaling pathway is depicted to highlight known examples of bona fide oncogenes that are subjected to dysregulation by various mechanisms. It is clear that a signaling pathway can be ...

Credit: Dr. Tetsuya Muramoto The study revealed the mechanisms by which periodic intracellular cAMP signal frequencies regulate transcription factor shuttling between the nucleus and cytoplasm and ...

Harvard researchers have mapped and cataloged more than 70,000 synaptic connections from about 2,000 rat neurons, using a ...

They then trained a deep learning model to predict what the intracellular signals looked like based solely on the extracellular recordings. In tests, their model created accurate and complete ...

The researchers collected a massive dataset—thousands of pairs of electrical signals—each pair linking an extracellular recording with its corresponding intracellular signal. The data included ...

The findings highlight the significance of frequency-selective cellular responses in developmental biology, providing valuable insights into the intercellular signal transduction mechanisms. More ...

The study revealed the mechanisms by which periodic intracellular cAMP signal frequencies regulate transcription factor shuttling between the nucleus and cytoplasm and multicellular structure ...