Scientists in the laboratory of Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of ...

Mitochondria are crucial organelles for cellular homeostasis, regulating processes such as ATP production, reactive oxygen species (ROS) management and Ca2+ signaling.

New guidelines create clarity of language that will help advance mitochondria transfer and transplantation research for ...

The findings highlight the potential of targeting mitochondrial function specifically in immune cells to treat a range of inflammation-related diseases. “Therapies aimed at improving mitochondrial ...

where impaired mitochondrial dynamics contribute to heart disease. The mitochondrial quality control (MQC) system, which includes fission, fusion, and mitophagy, is crucial for maintaining ...

Mitochondria are central to energy production in cells, and their dysfunction is increasingly implicated in the aging process and the pathogenesis of ...

thereby stimulating metabolism and regulating processes that are sensitive to Ca 2+. This Review discusses mitochondrial calcium trafficking and its dysregulation in disease.

The B vitamin mitigates manganese neurotoxicity, which produces symptoms that resemble Parkinson's disease. The vitamin improves dopamine production in the brain and offers potential therapeutic ...