A single amino acid change in a neuronal ion channel called KCNQ2 blocks ion flow, prevents protein localization on axons, and results in severe epilepsy and slowed neurological development.

The question of putative mechanisms of action continues to haunt psychopharmacology. Put simply, we know these drugs work, but we have very little idea how. We make guesses based on the ...

They obtained biopsies from volunteers to investigate the molecular mechanism behind this. “When you did the skin biopsy with the punch in the athletes, it was crunching [like] an apple, like it felt ...

China, South Korea, and the Philippines have temporarily halted imports of Canadian beef where an “atypical” case of bovine spongiform encephalopathy (BSE), commonly known as mad cow disease ...

Employing gene-technological methods such as CRISPR-Cas9 genome editing, they were able to establish the molecular mechanisms of how mitochondria counteract cellular NAD decline. "Decreased ...

New research identifies key cellular mechanism driving Alzheimer's disease. ScienceDaily . Retrieved January 19, 2025 from www.sciencedaily.com / releases / 2024 / 12 / 241223135051.htm ...

A research team from the University of California, Irvine has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. This ...

The paper entitled "Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy" by Abreo et al. is a complex and integrated paper that is well-written with a focus on a single gene ...

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.macromol.4c01893.

Neonatal encephalopathy, a condition resulting from perinatal asphyxia, occurs in 2.0–6.0 of every 1000 live births. Without treatment, prognosis is poor and resulting complications such as ...