While peptides are usually produced by non-ribosomal peptide synthetases, polyketides are produced by polyketide synthases.

An important topic at the meeting was the structural biology of polyketide synthesis, an area in which recent advances are certain to have a transforming effect on future research. Polyketides ...

Extensive strain screening has identified many useful polyketide derived compounds of both 'macrolide' and 'polyaromatic' type produced by bacteria. In order to understand the biosynthetic processes ...

Team's focus on polyketide synthetase enzyme One major challenge in treating TB is that the bacteria can form a protective ...

The overall strategy is perhaps best exemplified in Enders' elegant synthesis of callystatin A, a polyketide natural product that inhibits the growth of cancer cells, but that can only be isolated ...

The work of his group on giant multifunctional enzymes involved in fatty acid synthesis offer first mechanistic insights into substrate shuttling and delivery in such megasynthases, with direct ...

Enzymes are extraordinary biocatalysts –they are the machinery within cell factories crafted by Nature over aeons of evolution. The aims of my research are focused upon using techniques in synthetic ...

He introduced me to biosynthesis and I left Australia to join Professor Jim Staunton's lab to study polyketide biosynthesis. Both he and Professor David Cane (where I did my postdoc research) were ...