What challenges arise in characterizing LNPs compared to proteins ... with size-exclusion chromatography to quantify absolute molar mass, size, conformation, conjugation and aggregation ...

inverse size-exclusion chromatography (ISEC) or imaging methods such as electron microscopy or X-ray tomography, which require special equipment and complex evaluation. Tracers can be pore penetrating ...

Size Exclusion Chromatography (SEC) Analysis of Proteins To assess oligomeric state of the fusion ... fusion form results in the exposure of the hydrophobic fusion peptide and aggregate formation.

These salivary proteins include different factors that can impair normal host immune responses, stop platelet aggregation ... they performed size exclusion chromatography and mass spectrometry to ...

A panel of mammalian cell lines is suitable for the production of biopharmaceuticals [22] exist but the main workhorses for recombinant protein production ... frozen purified IgM preparations by size ...

University College London scientists recently created a new technique for selecting two-dimensional liquid chromatography (2D ...

In this installment, I primarily discuss considerations to keep in mind when choosing buffering additives that will be used ...

These aggregates can compromise product efficacy, elevate immunogenicity risks and complicate purification strategies. This whitepaper explores how innovative chromatography solutions can improve ...

Researchers at the VIB-KU Leuven Center for Microbiology and the VIB-KU Leuven Center for Brain & Disease Research have ...