The San Francisco 49ers could hardly afford any more offensive injuries. Running back Christian McCaffrey has been out for the entire season, while wide receiver Deebo Samuel barely played in Week 7 ...

San Francisco 49ers star receiver Brandon Aiyuk will miss the rest of the season after tearing ligaments in his right knee.

The 49ers and wide receiver Brandon Aiyuk got the worst news on his injured right knee. According to a report from Fox Sports ...

This week’s 49ers mailbag is stocked with questions (and answers) regarding their offensive shortcomings, fourth-quarter ...

Drake London and Tyler Lockett are among UPI senior sports writer Alex Butler's four must-start wide receivers for Week 8 of ...

The San Francisco 49ers just lost star receiver Brandon Aiyuk for the season because of a devastating knee injury, leaving ...

San Francisco 49ers legend Jerry Rice offered advice to Brandon Aiyuk as the 26-year-old wide receiver deals with the recovery process from a torn ACL and MCL.

San Francisco 49ers face offensive challenges as injuries mount, leaving Purdy with limited options in loss to Kansas City ...

On Monday, San Francisco 49ers wide receiver Deebo Samuel expressed his support for his injured teammate, Brandon Aiyuk. Head ...

San Francisco 49ers wide receiver Brandon Aiyuk (11) is hit by Kansas City Chiefs cornerback Trent McDuffie, left, and safety ...

The San Francisco 49er can't seem to catch a break this season and more injuries are piling up for the franchise.