Background Colorectal cancer (CRC) is a common and preventable disease for which screening rates by colonoscopy remain unacceptably low. Our primary objective was to develop and validate a clinical ...

In an attempt to study the relative toxicity of anthraquinonic laxatives on intestinal mucosa, we compared in mice the effects of fruit pulp containing sennosides A and B with those of a free ...

Correspondence to Dr Citadel J Cabasag, Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France; cabasagc{at}fellows.iarc.fr We read with interest the commentary by ...

Background Mounting epidemiological evidence supports a role for phosphatase and tensin homologue (PTEN)-T cell leukaemia 1 (Tcl1) signalling deregulation in hepatocarcinogenesis. Objective To ...

2 Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA 3 Translational Research Center for Gastrointestinal ...

Correspondence to Dr Feng Sun, Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China; sunfeng{at}bjmu.edu.cn SS and QY contributed equally.

University of Technology of Compiègne, UMR CNRS 6600 – Biomechanics and Bioengineering, Compiègne, France Correspondence to Dr C Legallais, UTC, UMR CNRS 6600 Biomechanics and Bioengineering, BP 20529 ...

Objective Cancer-associated fibroblasts (CAFs) influence the tumour microenvironment and tumour growth. However, the role of CAFs in colorectal cancer (CRC) development is incompletely understood.

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Dr A L Warshaw, W Gerald Austen Professor of Surgery, Surgeon-in-Chief, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. Background—Ectopic protease activation, microcirculatory ...

1 Department of Gastroenterology, Barts and The London NHS Trust, London, UK 2 Upper Gastrointestinal Physiology Unit, Barts and the London School of Medicine and Dentistry, London, UK 3 Department of ...

1 Dalhousie Inflammation Group and Department of Pediatrics, and Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada 2 Dalhousie Inflammation Group and ...