Background Colorectal cancer (CRC) is a common and preventable disease for which screening rates by colonoscopy remain unacceptably low. Our primary objective was to develop and validate a clinical ...

Objective Over half of patients with IBS have either diarrhoea (IBS-D) or a mixed stool pattern (IBS-M). The relative efficacy of licenced pharmacological therapies is unclear in the absence of ...

One hundred and eight patients with ileostomies were investigated for cholelithiasis at routine annual review in a large Ileostomy Clinic. Gallstones were demonstrated in 24-5%, which is three times ...

2 Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Tianjin, China Objective Hepatitis B virus (HBV ...

Introduction Transcriptional analyses have identified several distinct molecular subtypes in pancreatic ductal adenocarcinoma (PDAC) that have prognostic and potential therapeutic significance.

Objective Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor expressed in tissues with high oxidative activity that plays a central role in metabolism. In this work, we ...

Correspondence to Dr Manasi Agrawal, The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; manasi.agrawal{at}mountsinai.org ...

Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common chronic liver disease globally and is currently estimated to affect up to 38% of the global adult population. NAFLD is a ...

1 State Key Laboratory of Systems Medicine for Cancer, Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2 Centre ...

Correspondence to Dr Citadel J Cabasag, Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France; cabasagc{at}fellows.iarc.fr We read with interest the commentary by ...

The Lyon Consensus provides conclusive criteria for and against the diagnosis of gastro-oesophageal reflux disease (GERD), and adjunctive metrics that consolidate or refute GERD diagnosis when primary ...

Endoscopic sphincterotomy to prevent post-ERCP pancreatitis after self-expandable metal stent placement for distal malignant biliary obstruction (SPHINX): a multicentre, randomised controlled trial ...