Safeguarding intestinal stem cells during aging through balanced signaling
A recent study led by Associate Professor Takuya Yamamoto and Researcher May Nakajima-Koyama has revealed that maintaining a delicate balance between interferon-gamma (IFN-γ) and extracellular ...
Nature3d
Wnt signalling and its impact on development and cancer
Future research will therefore demonstrate how important the Wnt–β-catenin signalling pathway is for the self-renewal of cancer stem cells. The past two decades have seen a number of cases in ...
gut.bmj4d
O43 The phenotype and TCR repertoire of intestinal CD8+ T cells is altered in coeliac disease
Introduction Coeliac disease (CD) is a common immune-mediated condition driven by aberrant adaptive CD4+ T cell responses to gluten. The cytotoxic CD8+ and γδ+ T cell response in the epithelium is ...
gut.bmj6d
Cytokine profiles of cultured microvascular endothelial cells from the human intestine
been chiefly studied in human umbilical vein endothelial cells (HUVEC) but, because tissue-specific differences apparently exist, the role of human intestinal microvascular endothelial cells (HIMEC) ...