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The brewpub's lease expired and the landlord told its owners that repairs were needed, Schlafly said in a statement.
Schlafly in recent years opened a location in Highland, Illinois, and has operated other brewpubs in the region for 30 years.
The Clydesdale became associated with Budweiser after the sons of August A. Busch Sr. gave him six horses and a hitch in 1933 to commemorate the repeal of Prohibition.