Various injury factors, including viral infection, alcohol, obesity, and insulin resistance, act on the liver, causing liver inflammation, an immune response, hypoxia, oxidative stress, hepatocyte ...
A liver biopsy targeting the masses was performed on 11 March 2013. Some hepatocytes showed hydropic degeneration. Spotty necrosis and focal necrosis could be easily seen. Some areas showed ...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various tumor cells in vitro, but its physiological role in tumor surveillance remains unknown. Here ...
Alcoholic steatohepatitis with neutrophilic acute hepatitis and associated hepatocellular necrosis. Mild microvesicular and macrovesicular steatosis are observed, and architectural disarray ...
Each cytokine acts through its own receptor on target cells, and these receptors include members of the immunoglobulin (Ig) superfamily and tumour necrosis factor (TNF). Cell-type-specific SARS ...
Our mission is to provide a state-of-the-art facility, expertise, and education in advanced quantitative light microscopy to support Drexel University’s research community The Cell Imaging Center (CIC ...
as cell membrane stabilisers and permeability regulators that prevent hepatotoxic agents from entering hepatocytes; (iii) as promoters of ribosomal RNAsynthesis, stimulating liver regeneration ...
In summary, the expression of ferroptosis markers GPX4 and SLC7A11 is regulated by the AKT/GSK3β/β-catenin signaling pathway, and PFOA may promote hepatocyte ferroptosis by inhibiting this pathway.
Background and aim: The importance of the hepatocyte ploidisation pattern to the control of cell proliferation and differentiation has been well established. However, there are no data that have ...
NR2F6 is an intracellular immune checkpoint, directly repressing transcription of cytokine genes in T cells relevant for cancer cell rejection, such as interleukin-2, interferon γ and tumour necrosis ...
In contrast, bilirubin elevations, without raised ALT/AST, were more common with tocilizumab, possibly a pharmacodynamic effect of hepatocyte IL6R inhibition. Modifications of dosing in response to ...