The potent extrafollicular B cell response and activated GZMK + CD8 T cells may form a vicious circle and unique ecosystem, which may underlie the pathogenesis in lupus kidney. These findings may ...

Neuropsychiatric systemic lupus erythematosus (NPSLE), or central nervous system lupus, can be challenging to diagnose ...

To date, treatment with NIM-1324 has reduced the production of interferon alpha in human peripheral blood mononuclear cells (PBMCs) from systemic lupus erythematosus (SLE) patients and provided ...

Lupus (systemic lupus erythematosus) and multiple sclerosis can appear similar in many ways. Both lupus and MS are chronic autoimmune diseases. More than 100 different autoimmune diseases exist, with ...

Pathogenesis is the term that is used to describe ... Treating a mouse model of systemic lupus erythematosus with simvastatin (an inhibitor of this pathway) led to recovery from dysregulation ...

Sept 30 (Reuters) - Kezar Life Sciences (KZR.O), opens new tab said on Monday it has paused a trial of its experimental drug for lupus to review safety data after four patients died in the mid ...

Now, the company has hit the brakes on its phase 2b study of the drug in lupus nephritis following four patient fatalities. An independent data monitoring committee (IDMC) recommended suspending ...

Genentech announced positive results from the Phase III study (REGENCY) of Gazyva (Obinutuzumab) for people with active lupus nephritis (LN). Gazyva is an engineered humanized monoclonal antibody ...

Sept 24 (Reuters) - Biogen (BIIB.O), opens new tab and Belgian partner UCB (UCB.BR), opens new tab said on Tuesday their experimental lupus treatment met the main goal of a late-stage trial in ...

Research over the past decade has revealed multiple potential mechanisms by which dendritic cells contribute to the immunopathogenesis of systemic lupus erythematosus. Genetic abnormalities in ...

Future Rheumatol. 2008;3(3):269-279. These phenotypic abnormalities, at least in part, appear to be intrinsic to the mDCs, as the addition of lupus serum to healthy control or lupus mDCs could not ...