and we hope future research could lead to the development of genetic therapy treatments for those with rarer CF mutations too,” said Lucy Allen, a lung biologist and research director at Cystic ...

Despite new medication, cystic fibrosis often leads to permanent lung damage. Working with an international team, researchers ...

Sharma J, et al: A novel G542X CFTR rat model of cystic fibrosis is sensitive to nonsense mediated decay ... and additional approaches for rare CFTR mutations not yet addressed Core Function #2: ...

In a study published in Nature Communications, scientists reported a novel strategy to deliver the CRISPR-Cas9 gene-editing system into the lungs of a cystic fibrosis mouse model and correct the ...

inhibition because the G542X mutation was introduced into the mouse Cftr locus and thus the transcript is spliced normally and is subject to NMD. CF null (CFTR-/-) rat: The first CF rat model, ...

Perinatal dysfunction of innate immunity in cystic fibrosis.Sci. Transl. Med.17,eadk9145 (2025).DOI:10.1126/scitranslmed.adk9145 ...

New study suggests why mice with cystic fibrosis mutations can stave off bacterial infections in their lungs. People who have cystic fibrosis are susceptible to bacterial infections in their lungs.

In 1997, the National Institutes of Health convened a Consensus Development Conference on Cystic Fibrosis (CF). 1 The Consensus Conference recommended that genetic screening for CF mutations ...

The Massachusetts-based biotech plans to use the funds to push its candidates into mid-stage clinical trials in a space ...

An international study has identified two types of these so-called dysbioses in cystic fibrosis. They display ... Landmark Study Involving Babies in Ireland Supports Use of Cystic Fibrosis Drug in ...

Patients aged 6 to 11 years with cystic fibrosis receiving 24-week once-daily vanzacaftor/tezacaftor/deutivacaftor generally ...

Initially, CF was thought to be caused by nutritional deficiencies, persistent infection, and many others —until in 1989, ...