Dr. Lynne Maquat, a mechanistic biochemist and the director of the University of Rochester Center for RNA Biology, was ...

Messenger RNA (mRNA) serves as a blueprint for proteins. When mRNA is no longer needed, it must be degraded. Director Elena ...

Lynne E. Maquat, PhD, director of the Center for RNA Biology at the University of Rochester, has been awarded the 2024 Albany ...

The structure of a human exosome–ribosome supercomplex reveals the mechanisms behind the formation of active cytoplasmic exosomes and their role in co-translational RNA decay. The prokaryotic ...

The distribution of radiation throughout the body, whether in a target organ or more systemically (e.g., circulating blood), ...

“A truncated protein might cause a lot of problems … Nonsense mediated decay is a mechanism to get rid of that RNA before it's translated into a protein.” Alternative splicing plays a pivotal role in ...

finished RNA only. Unproductive transcripts are quickly destroyed by a cellular process called nonsense-mediated decay (NMD). Li's team calculated that on average, about 15% of transcripts that are ...

In 2013, researchers found that proteins known as 'RNA decay factors' responsible for mRNA degradation are actively moved from the cell’s cytoplasm into its nucleus to instruct the transcription ...

RNA stability, important for eukaryotic gene expression ... To clarify the role of deadenylation in mRNA decay, we first modeled mRNA poly(A) tail kinetics and mRNA stability in yeast. Independent of ...