Journey of Voyager’s ALS gene therapy to clinic hindered by need to find alternative payload
The candidate in question is VY9323, an AAV gene therapy combining a highly potent pri-miRNA against superoxide dismutase 1 (SOD1) with an intravenous-delivered, blood-brain barrier-penetrant TRACER capsid. The company originally planned to begin a phase 1 trial of VY9323 in ALS in mid-2025.