Background Colorectal cancer (CRC) is a common and preventable disease for which screening rates by colonoscopy remain unacceptably low. Our primary objective was to develop and validate a clinical ...

Objective Over half of patients with IBS have either diarrhoea (IBS-D) or a mixed stool pattern (IBS-M). The relative efficacy of licenced pharmacological therapies is unclear in the absence of ...

One hundred and eight patients with ileostomies were investigated for cholelithiasis at routine annual review in a large Ileostomy Clinic. Gallstones were demonstrated in 24-5%, which is three times ...

Introduction Transcriptional analyses have identified several distinct molecular subtypes in pancreatic ductal adenocarcinoma (PDAC) that have prognostic and potential therapeutic significance.

Correspondence to Dr Citadel J Cabasag, Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France; cabasagc{at}fellows.iarc.fr We read with interest the commentary by ...

Correspondence to Dr Johann von Felden, Department of Internal Medicine, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; j.von-felden{at}uke.de; Dr Augusto Villanueva, Liver Cancer Program, ...

University of Technology of Compiègne, UMR CNRS 6600 – Biomechanics and Bioengineering, Compiègne, France Correspondence to Dr C Legallais, UTC, UMR CNRS 6600 Biomechanics and Bioengineering, BP 20529 ...

With the growing number of novel therapeutic approaches for liver diseases, significant research efforts have been devoted to the development of liquid biopsy tools for precision medicine. This can be ...

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Objective Cancer-associated fibroblasts (CAFs) influence the tumour microenvironment and tumour growth. However, the role of CAFs in colorectal cancer (CRC) development is incompletely understood.

Dr A L Warshaw, W Gerald Austen Professor of Surgery, Surgeon-in-Chief, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. Background—Ectopic protease activation, microcirculatory ...

Correspondence to Dr Feng Sun, Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing 100191, China; sunfeng{at}bjmu.edu.cn SS and QY contributed equally.